Sham Surgery and Reasonable Risk
نویسنده
چکیده
منابع مشابه
Ethical Aspects of Placebo (“sham”) Surgery
in a limited fashion in orthopaedic research but is not without controversy. The debate over sham surgery controls involves two predominant issues. The first is whether a randomized clinical trial with sham surgery control is a scientifically superior method to test either novel or questionably effective interventions for orthopaedic conditions. Secondly, one must ask whether the risks to subje...
متن کاملSham Surgery and Reasonable Risks
O of the most fundamental tensions within clinical research arises from the need to balance the goal of advancing the frontiers of science in order to improve the standard of care available to future persons with the goal of responding with diligence and compassion to the important interests and health needs of the research participants who make such progress possible (Jonas 1969; see also Lond...
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Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects receiving the procedure was small. Harm occurred more frequently in subjects r...
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BACKGROUND Remote ischemic preconditioning is a simple therapy that may reduce cardiac and kidney injury. We undertook a randomized controlled trial to evaluate the effect of this therapy on markers of heart and kidney injury after cardiac surgery. METHODS Patients at high risk of death within 30 days after cardiac surgery were randomly assigned to undergo remote ischemic preconditioning or a...
متن کاملSham surgery controls are
Debate continues about the ethics of sham surgery controls. The most powerful argument for sham surgery controls is that rigorous experiments are needed to demonstrate safety and efficacy of surgical procedures. Without such experiments, there is danger of adopting worthless procedures in clinical practice. Opponents of sham surgery controls argue that sham surgery constitutes unacceptable viol...
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